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2016•International Journal of PhytomedicineOpen access

Hepatoprotective Activity of Aqueous Extract of Sesbania grandiflora Linn Leaves against Carbon Tetrachloride induced Hepatotoxicity in Albino Rats

Dayananda Bhoumik, Arunabha Mallik, Abera Hadgu Berhe

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Abstract

The present study was conducted to evaluate the hepatoprotective activity of aqueous extract of leaves of per oral using Carbon tetrachloride induced liver damage in wistar albin showed significant (p<0.05)hepatoprotective effect by lowering the serum levels of various biochemical parameters such as serum glutamic oxaloacetate transaminase (SGOT), serum glutamic pyruvates transaminase (SGPT), alkaline phosp cholesterol (CHL) and by increasing the levels of total protein (TPTN) and albumin (ALB), in the selected model.These biochemical observations were inturn confirmed by histopathological examinations of liver secti hepatoprotective drug Silymarin (100 mg/kg body weight i.p.) which served as a reference control.It was concluded from the result that the aqueous extract of possesses hepatoprotective acti

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The present study was conducted to evaluate the hepatoprotective activity of aqueous extract of leaves of per oral using Carbon tetrachloride induced liver damage in wistar albin showed significant (p<0.05)hepatoprotective effect by lowering the serum levels of various biochemical parameters such as serum glutamic oxaloacetate transaminase (SGOT), serum glutamic pyruvates transaminase (SGPT), alkaline phosp cholesterol (CHL) and by increasing the levels of total protein (TPTN) and albumin (ALB), in the selected model.These biochemical observations were inturn confirmed by histopathological examinations of liver secti hepatoprotective drug Silymarin (100 mg/kg body weight i.p.) which served as a reference control.It was concluded from the result that the aqueous extract of possesses hepatoprotective acti

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Available abstract

The present study was conducted to evaluate the hepatoprotective activity of aqueous extract of leaves of per oral using Carbon tetrachloride induced liver damage in wistar albin showed significant (p<0.05)hepatoprotective effect by lowering the serum levels of various biochemical parameters such as serum glutamic oxaloacetate transaminase (SGOT), serum glutamic pyruvates transaminase (SGPT), alkaline phosp cholesterol (CHL) and by increasing the levels of total protein (TPTN) and albumin (ALB), in the selected model.These biochemical observations were inturn confirmed by histopathological examinations of liver secti hepatoprotective drug Silymarin (100 mg/kg body weight i.p.) which served as a reference control.It was concluded from the result that the aqueous extract of possesses hepatoprotective acti

Key concepts: Carbon tetrachloride, Chemistry, Albumin, Transaminase, Bilirubin, Traditional medicine, Pharmacology, Alanine transaminase

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Hepatoprotective Activity of Aqueous Extract of Sesbania grandiflora Linn Leaves against Carbon Tetrachloride induced Hepatotoxicity in Albino Rats — Research Paper | ScholarLens