Clinical efficacy of magnesium isoglycyrrhizinate in treatment of patients with severe acute pancreatitis

Objective To explore the effect of magnesium isoglycyrrhizinate on clinical curative effect in patients with severe acute pancreatitis( SAP). Methods Ninety-two SAP patients were randomly divided into the treatment group( n = 46) and the control group( n = 46). They all accepted the conventional treatment,but the patients in the treatment group were given the treatment of magnesium isoglycyrrhizinate150 mg·d-1for 2 weeks. The difference of C reactive protein( CRP),tumor necrosis factor alpha( TNF-α),interleukin-6( IL-6),intercellular adhesion molecule-1( ICAM-1),oxygenation index,alanine aminotransferase,aspartate aminotransferase,blood creatinine,urea nitrogen and the incidence rate of adverse drug reactions were compared between the two groups. Results The total effective rate in the treatment group( 89. 13%) was significantly higher than that in control group( 69. 57%). After 7 d and 14 d of treatment,the CRP,TNF-α,IL-6,ICAM-1 in the treatment group were significantly lower than that in the control group( P 0. 05). After 7 d and 14 d of treatment,oxygenation index in the treatment group was significantly higher than that in the control group( P 0. 05), and alanineaminotransferase,aspartate aminotransferase,blood creatinine,urea nitrogen in the treatment group were significantly lower than that in the control group( P 0. 05). Conclusions Magnesium isoglycyrrhizinate could improve the clinical efficacy by improving inflammation and protecting organ function in SAP patients.