2004•Biaoji mianyi fenxi yu linchuangRequires access

Clinical Significance of Combined Determination of PGI, PGII and GAS for Diagnosis in Gastric Cancer

Rongjun Zhang

Abstract

To evaluate the clinical value of combined determination of PGⅠ, PGⅡ and GAS for early diagnosis in gastric cancer,the serum levels of PGⅠ, PGⅡ and GAS in 190 healthy controls and 129 gastric patients were measured by RIA. Of 129 patients, 68 caser were gastric cancer.The results showed that the serum levels of PGⅠ and PGⅠ/PGⅡ ratio in gastric cancer patients were obviously lower than that in healthy controls and the serum GAS levels were significantly higher. The sensitivity of combined determination of PGⅠ, PGⅡ and GAS for gastric cancer diagnosis was 94.2% and the specificity 73.4% respectively.All these results indicated that determination of serum PGⅠ,PGⅡ and GAS levels may be used as a tools for primary screening gastric cancer.

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Key concepts: Medicine, Gastroenterology, Cancer, Internal medicine, Clinical significance, Clinical diagnosis, Intensive care medicine