Clinical significance of serum pepsinogen levels in gastric diseases

Objective: To evaluate the relationship between serum pepsinogen level and gastric diseases.Methods: Serum pepsinogenⅠandⅡlevels were measured by radioimmunoassay in 197 healthy controls,and 273 patients with gastric diseases.The results were analyzed by statistics.Results: Compared with healthy controls,the serum PGⅠlevels of duodenal ulcer patients and serum PGⅡlevels of gastric ulcer were significantly higher.The serum PGⅠlevels of gastritis patients were significantly lower and the serum PGⅠlevels and PGⅠ/PGⅡratio of gastric cancer patients were much more lower.Using the cutoff value of 35 μg/L for PGⅠand 1.5 for PGⅠ/PGⅡratio,the sensitivity and specificity of the combined tests for gastric cancer were 72.4.6% and 84.0%,respectively.Conclusion: The changes of serum PGⅠand PGⅡlevels are valuable for diagnosis of gastric cancer and gastric pathological changes.