2008•Chinese Journal of Natural MedicinesRequires access

Two Antifungal Active Triterpene Glycosides from Sea Cucumber Holothuria (Microthele) axiloga

Yuan Wei

Abstract

AIM:To study the new antifungal active triterpene glycosides of sea cucumber Holothuria (Microthele) axiloga. METHODS: Triterpene glycosides from Holothuria (Microthele) axiloga were separated and purified by silica gel chromatography,reversed-phase silica gel chromatography and RP-HPLC. Their structures were elucidated on the basis of chemical evidence,spectral data and chemical reactions. RESULTS: Two triterpene glycosides were identified as axilogoside A (1) and holothurin B (2). CONCLUSION: Axilogoside A (1) is a new triterpene glycoside,and 2 was isolated from Holothuria (Microthele) axiloga for the first time. They showed considerable antifungal activities (4≤MIC80≤16 μg ·mL-1).

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Key concepts: Sea cucumber, Triterpene, Glycoside, Antifungal, Chemistry, Saponin, Silica gel, Chromatography