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Cytotoxicitic triterpene glycosides from sea cucumber Holothuria scabra Jaeger

Sun Peng

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Abstract

Aim To study the bioactive triterpene glycosides of sea cucumber Holothuria scabra Jaeger.Methods Triterpene glycosides in the sea cucumber were isolated and purified by column chromatography on DA-101,silica gel,reversed-phase silica and reversed HPLC.Their chemical structure were identified on the basis of chemical evidence and spectral data.The cytotoxicities of the compounds obtained were tested with HL-60 cells and MOLT-4 cancer cells.Results Five triterpene glycosides were obtained from the sea cucumber studied and their structures were identified as scabraside C(1),holothurin A1(2),echinoside A(3),24-dehydroechinoside A(4) and holothurin A(5).Their inhibition activities on HL-60,MOLT-4 and A-549 cells were significant.Conclusion Compounds 15 are obstained from Holothuria scabra Jaeger for the first time.All glycosides good show antitumor activity in vitro.

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Aim To study the bioactive triterpene glycosides of sea cucumber Holothuria scabra Jaeger.Methods Triterpene glycosides in the sea cucumber were isolated and purified by column chromatography on DA-101,silica gel,reversed-phase silica and reversed HPLC.Their chemical structure were identified on the basis of chemical evidence and spectral data.The cytotoxicities of the compounds obtained were tested with HL-60 cells and MOLT-4 cancer cells.Results Five triterpene glycosides were obtained from the sea cucumber studied and their structures were identified as scabraside C(1),holothurin A1(2),echinoside A(3),24-dehydroechinoside A(4) and holothurin A(5).Their inhibition activities on HL-60,MOLT-4 and A-549 cells were significant.Conclusion Compounds 15 are obstained from Holothuria scabra Jaeger for the first time.All glycosides good show antitumor activity in vitro.

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Available abstract

Aim To study the bioactive triterpene glycosides of sea cucumber Holothuria scabra Jaeger.Methods Triterpene glycosides in the sea cucumber were isolated and purified by column chromatography on DA-101,silica gel,reversed-phase silica and reversed HPLC.Their chemical structure were identified on the basis of chemical evidence and spectral data.The cytotoxicities of the compounds obtained were tested with HL-60 cells and MOLT-4 cancer cells.Results Five triterpene glycosides were obtained from the sea cucumber studied and their structures were identified as scabraside C(1),holothurin A1(2),echinoside A(3),24-dehydroechinoside A(4) and holothurin A(5).Their inhibition activities on HL-60,MOLT-4 and A-549 cells were significant.Conclusion Compounds 15 are obstained from Holothuria scabra Jaeger for the first time.All glycosides good show antitumor activity in vitro.

Key concepts: Sea cucumber, Triterpene, Glycoside, Chemistry, Silica gel, Column chromatography, Stereochemistry, Chromatography

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