Observation of curative effect of treating the chronic hepatitis B patients by telbivudine combined with Adefovir dipivoxil.

Aim To evaluate the curative effect of treating the Chronic hepatitis B patients by Telbivudine combined with Adefovir dipivoxil.Methods 84 patients were divided into 3 groups at random in order to observe the changes of HBV-DNA,HBeAg/HBeAg serological conversion rate and ALT among three groups.Results After treating 12 and 24 weeks,the level of HBV-DNA and ALT were decreased in comparison with those before treatment(P0.05).After 12 weeks treatment,the level of HBV-DNA and ALT of combination therapy group was better than the Adefovir dipivoxil group's that has statistical signficance(P0.05).After 24 weeks,combination therapy group were better than the Adefovir dipivoxil group in three main outcome measures which has signficant difference.Conclusion There are more powerful antiviral ability of treating CHB patients by Telbivudine combine with Adefovir dipivoxil.The combination therapy can minimize the resistance and increase the anti-viral effect.