Study on bioavailability of complex chlorzoxazone dispersible tablet in healthy volunteers

OBJECTIVE To compare the pharinacokinetics and relative bioavailability of complex chlorzoxazone tablet. METHODS In randomized crossover design,asingle dose complex chlorzoxazone tablet was given to 18 healthy male volunteers. The plasma concentrations of chlorzoxazone and paracetamol were determined by HPLC method. RESULTS The pharmacokinetie parameters of the two products were included: c max were(19.7±5 9 )and( 19.4 ± 5.9)μg·mL-1;t1/2were( 1.3 ± 0.5)and( 1.1 ±0.2)h;AUC were(50.6± 18.3)and(52.8± 19 8) μg·h·mL 1 , respectively. The mean relative bioavailability of the two tablets was(96.6 ± 8.8)% .CONCLUSION The results suggested that these two products were ralative bioavailability.