ScholarLens Back to search
1996•Chinese Journal of Clinical PharmacyRequires access

PHARMACOKINETICS AND RELATIVE BIOAVAILABILITY OF CHLORZOXAZONE TABLET IN 10 HEALTHY VOLUNTEERS

Hongwei Zhang

Open publisher page 0 citations

Abstract

A pharmacokinetics and relative bioavailability study of randomized cross-over design was carried out in ten healthy men who were given a single oral dose of chlorzoxazone in either of the two tablet formulations. Serum levels were determined by HPLC method. The concentration-time curve was fitted with a one compartment model. The pharma-cokinetic parameters of the detected tablet were as follows Cmax=12.30±3.74μg/ml, Tmax=1.13±0.23h, K=0.88±0.15h-1, T=0.81±0.14h, AUC0-8h=31.49±10.60μg·h/ml,In comparison with the standard tablet, the detected tablet is bioequivalent.

About this research paper

What this paper is about

A pharmacokinetics and relative bioavailability study of randomized cross-over design was carried out in ten healthy men who were given a single oral dose of chlorzoxazone in either of the two tablet formulations. Serum levels were determined by HPLC method. The concentration-time curve was fitted with a one compartment model. The pharma-cokinetic parameters of the detected tablet were as follows Cmax=12.30±3.74μg/ml, Tmax=1.13±0.23h, K=0.88±0.15h-1, T=0.81±0.14h, AUC0-8h=31.49±10.60μg·h/ml,In comparison with the standard tablet, the detected tablet is bioequivalent.

Why it matters

A significance statement is not available in the OpenAlex record.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

A pharmacokinetics and relative bioavailability study of randomized cross-over design was carried out in ten healthy men who were given a single oral dose of chlorzoxazone in either of the two tablet formulations. Serum levels were determined by HPLC method. The concentration-time curve was fitted with a one compartment model. The pharma-cokinetic parameters of the detected tablet were as follows Cmax=12.30±3.74μg/ml, Tmax=1.13±0.23h, K=0.88±0.15h-1, T=0.81±0.14h, AUC0-8h=31.49±10.60μg·h/ml,In comparison with the standard tablet, the detected tablet is bioequivalent.

Key concepts: Bioequivalence, Chlorzoxazone, Bioavailability, Cmax, Pharmacokinetics, Pharmacology, Chromatography, Chemistry

Related papers

Related paper 1Related paper 2Related paper 3
Back to paper searchBrowse research topicsOriginal source
PHARMACOKINETICS AND RELATIVE BIOAVAILABILITY OF CHLORZOXAZONE TABLET IN 10 HEALTHY VOLUNTEERS — Research Paper | ScholarLens