Clinical study on the effect of Domperidone on electrogastrogram of the patients with functional dyspepsia

Objective To investigate the curative effect of Domperidone in treating functional dyspepsia (FD),to observe the changes of electrogastmgram in these patients both before and after meal,and to investigate the mechanism of Dompefidone for treating FD.Methods Serf-control methods were used for study.31 patients with functional dyspepsia selected randomly committed to symptom score after they stopped taking medicine that affected gastric acid secretion for a week.Then the changes of eleetrogastrogram were detected before meal with emptying of stomach.After patients took orally Domperidone for two weeks,electrogastrogram and symptoms score were detected again under the same condition.Results 2 weeks after treatment with oral Domperidone,the patients had signifi- cant improvement in upper abdominal pain,abdominal distension and belching.The symptom 8core changed from 48.20±21.71 to 19.00±11.03(P<0.01).The gastric emptying rate for 2 hours and 5 hours increased signifi- cantly after treatment(P<0.01).As for the gastric electrical activity parameter:①basic frequency changed from (2.57±0.60)cpm to(3.00±0.26)cpm before meal,and changed from (2.70±0.53)cpm to(3.01±0.27) cpm(P<0.05 for each).②main power-experimental group's main power changed from(55.36±8.46)μV to (75.06±13.13)μV before treatment and meal.and changed from(72.30±10.35)μV to(112.27±17.27)μV after meal and treatment(P<0.05).③Slow wave of gastric electrical activity(N%)increased significantly (54.8%→93.4%)(P<0.01).Bradygastria(B%)reduced significantly(19.4%→3.2%)(P<0.01).Tachyg- astria(T%)reduced significantly(25.8%→3.2%)(P<0.01).Conclusion Dompefidone has significant effect in improving some major symptoms like upper abdominal pain,abdominal distension and belching-and may strength- en gastric emptying,increase basic frequency and main power of electrngastrngram,so to convert the disturbed gastric electrical activity to normal. Key words: Domperidone;  Functional dyspepsia;  Electrogastrogram