The effect of periodontal initial therapy on chronic periodontitis and subgingival periodontal pathogen

PURPOSE: To evaluate the effect of periodontal initial therapy on clinical parameters and subgingival periodontal pathogen in patients with chronic periodontitis. METHODS: One hundred and twenty patients with chronic periodontitis were included. Probing depth (PD), attachment loss (AL), plaque index (PLI) and gingival index (GI) were evaluated at baseline and after-initial therapy. P.g and A.a in subgingival plaque were investigated by real-time PCR. Data was statistically analyzed by SAS6.12 software for Student’s t test. RESULTS: The PD, AL, PLI and GI were significantly decreased after periodontal initial therapy (P0.01), and meanwhile the ratio of P.g versus total bacteria was significantly decreased after-initial therapy (P0.05). However, the change of ratio of A.a versus total bacteria was not significant (P0.05). CONCLUSION: Periodontal initial therapy could effectively control the inflammation of chronic periodontitis, and decrease the ratio of P.g in subgingival plaque. Supported by National 11th Five-year Science and Technology Supporting Project(Grant No.2007BAI18B02) and Shen-Kang Research Fund of Shanghai Municipality(Grant No.SHDC12007210).