Effect of the levonorgestrel-releasing intrauterine device (Mirena) in the treatment of dysfunctional uterine bleeding

Objective To evaluate the efficacy and side-effect of the levonorgestrel-releasing intrauterine device (Mirena)with progesterone in the treatment of dysfunctional uterine bleeding. Methods 58 cases of dysfunctional uterine bleeding with pathologic diagnosis were inserted Mirena and the endometrial thickness by ultrasound 、hemoglobulin increasing and pathologic changes of endometria were detected before and after the insertion twenty-four months . Results The endometrial thickness before and after the insertion of Mirena were (16.5±7.3)mm and (3.1±1.4)mm respectively,which had a significant difference between them. After the insertion of Mirena, patients’ hemoglobulin was increased, and there was a significant difference between before and after insertion . After the insertion of Mirena , pathologic results showed it would reverse the endometrial hyperplasia .Conclusions Mirena is an effective and continual therapy for dysfunctional uterine bleeding. It can not only significantly reduce the menstrual blood loss but also reverse the endometrial hyperplasia effectively.