Effect of levonorgestrel-releasing intrauterine system on the treatment of patients with perimenopausal dysfunctional uterine bleeding

Objective: To investigate the clinical efficacy of levonorgestrel-releasing intrauterine system(LNG-IUS) on the treatment of patients with perimenopausal dysfunctional uterine bleeding,in order to provide a new theoretical basis for its clinical benefit in the effective and reasonable treatment of perimenopausal dysfunctional uterine bleeding and to reduce the uterus resection.Methods: 50 patients with perimenopausal dysfunctional uterine bleeding were treated with LNG-IUS.Results: After treatment of LNG-IUS,the menstrual blood volume reduced significantly,with statistical significance.Endometrial thickness reduced significantly after LNG-IUS placement.After 3-12 months treatment of LNG IUS,endometrium pathological examination showed that endometrial hyperplasia had been reversed in all cases.The endometrium exhibited visible secretion and a pseudo-decidual reaction.For 37 anemia patients,their anaemic condition was corrected during 3 months after the insertion.Conclusion: LNG-IUS is an efficient therapy for the menopausal transitional dysfunctional uterine bleeding and can reverse the endometrial hyperplasia effectively which make women during menopausal transition period go into menopause smoothly to avoid surgical removal of the uterus.