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2003•Zhonghua weizhongbing jijiu yixueRequires access

Expression of aquaporin4 protein in brain from rats with hemorrhagic edema

Sun Shan-qua

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Abstract

Objective: To study the expression of aquaporin4(AQP4) protein in perihematomal tissue after intracerebral hemorrhage(ICH) in rats. Methods: The experimental ICH m odel was established in rats by injecting quantitative collagenase into the left caudate nuclei of the rats. The changes of brain water content(BWC) were measur e d by the wet and dry weight methods. Immunohistochemistry was used to determine the change of expression of AQP4 protein during different periods after ICH. Results: BWC and AQP4 protein expression in perihematomal tissue were increased at 6 ho urs after ICH and reached peak at 72 hours. In one week following ICH, it was st il l higher than normal level. In addition, the expression of AQP4 was positively c orrelated with BWC(r=0 985 7,P0 01). Conclusion: AQP4 has a relevant relationship with the formation of brain edema after ICH.

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What this paper is about

Objective: To study the expression of aquaporin4(AQP4) protein in perihematomal tissue after intracerebral hemorrhage(ICH) in rats. Methods: The experimental ICH m odel was established in rats by injecting quantitative collagenase into the left caudate nuclei of the rats. The changes of brain water content(BWC) were measur e d by the wet and dry weight methods. Immunohistochemistry was used to determine the change of expression of AQP4 protein during different periods after ICH. Results: BWC and AQP4 protein expression in perihematomal tissue were increased at 6 ho urs after ICH and reached peak at 72 hours. In one week following ICH, it was st il l higher than normal level. In addition, the expression of AQP4 was positively c orrelated with BWC(r=0 985 7,P0 01). Conclusion: AQP4 has a relevant relationship with the formation of brain edema after ICH.

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Available abstract

Objective: To study the expression of aquaporin4(AQP4) protein in perihematomal tissue after intracerebral hemorrhage(ICH) in rats. Methods: The experimental ICH m odel was established in rats by injecting quantitative collagenase into the left caudate nuclei of the rats. The changes of brain water content(BWC) were measur e d by the wet and dry weight methods. Immunohistochemistry was used to determine the change of expression of AQP4 protein during different periods after ICH. Results: BWC and AQP4 protein expression in perihematomal tissue were increased at 6 ho urs after ICH and reached peak at 72 hours. In one week following ICH, it was st il l higher than normal level. In addition, the expression of AQP4 was positively c orrelated with BWC(r=0 985 7,P0 01). Conclusion: AQP4 has a relevant relationship with the formation of brain edema after ICH.

Key concepts: Medicine, Intracerebral hemorrhage, Brain edema, Immunohistochemistry, Brain tissue, Protein expression, Collagenase, Edema

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