Correlation between baseline blood glucose and disease severity:a survival analysis in critical cases

Objective To study the relationship between distribution of early baseline blood glucose(BG) and disease severity,and to perform a survival analysis in critical cases.Methods According to their baseline blood glucose during January and June of 2009,207 critical patients were divided into Group A(BG4.5 mmol/L),Group B(BG:4.5～8.3 mmol/L) and Group C(BG8.3 mmol/L).Statistical analysis on severity and prognosis was conducted for each group.Results(1)The APACHE Ⅱ scores of Group A(22.54±13.46) were significantly higher than those of Group B(10.30±6.23) and Group C(14.74±8.49),with statistical significance noted(P0.05);(2)The incidence of MODS,infections and use of vasoactive agents in Group A were 75%,62.5% and 50% respectively,which were significantly different from those in Groups B and C(P0.05);(3)Baseline blood glucose was significantly correlated with scores of APACHE Ⅱ,MODS and SOFA in Group A but only correlated with APACHE Ⅱ scores in Group C(P0.01);(4)According to survival analysis,28 d survival rate in Group A(54.2%) was significantly lower than in Groups B and C(P0.01).Conclusion Monitoring and evaluation of early baseline blood glucose may be an important approach to evaluation of severity and prognosis in critical cases.At a blood glucose level less than 4.5 mmol/L,early intervention and organ function protection should be initiated as quickly as possible.