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2003•Chinese Journal of Oral ImplantologyRequires access

Inhibiting Effect of EGFR Monoclonal Antibody on Proliferation of Oral Squamous Cell Carcinoma

HU Hai-shen

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Abstract

Objective To investigate the inhibiting effect of epidermal growth factor receptor(EGFRmAb)on proliferation of oral squamous cell carcinoma(SCC).Methods Tca8113squamous cell carcinoma cell line was treated with different concentration of EGFRmAb.Cell growth curve,clone inhibition rate,cell cycle redistribution and the expression of p27kip1were analyzed.Results EGFRmAb inhibited proliferation of oral SCC,leaded to elevation of cell proportion of G1phase cell,decreased the proportion of S phase cell and upregulated the express of p27kip1.Conclusion EGFRmAb inhibited the proliferation of oral SCC,which related with G1phase arrest of tumor cell.

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What this paper is about

Objective To investigate the inhibiting effect of epidermal growth factor receptor(EGFRmAb)on proliferation of oral squamous cell carcinoma(SCC).Methods Tca8113squamous cell carcinoma cell line was treated with different concentration of EGFRmAb.Cell growth curve,clone inhibition rate,cell cycle redistribution and the expression of p27kip1were analyzed.Results EGFRmAb inhibited proliferation of oral SCC,leaded to elevation of cell proportion of G1phase cell,decreased the proportion of S phase cell and upregulated the express of p27kip1.Conclusion EGFRmAb inhibited the proliferation of oral SCC,which related with G1phase arrest of tumor cell.

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Available abstract

Objective To investigate the inhibiting effect of epidermal growth factor receptor(EGFRmAb)on proliferation of oral squamous cell carcinoma(SCC).Methods Tca8113squamous cell carcinoma cell line was treated with different concentration of EGFRmAb.Cell growth curve,clone inhibition rate,cell cycle redistribution and the expression of p27kip1were analyzed.Results EGFRmAb inhibited proliferation of oral SCC,leaded to elevation of cell proportion of G1phase cell,decreased the proportion of S phase cell and upregulated the express of p27kip1.Conclusion EGFRmAb inhibited the proliferation of oral SCC,which related with G1phase arrest of tumor cell.

Key concepts: Cell growth, Cell, Cell cycle, clone (Java method), Cell culture, Basal cell, Cancer research, Epidermal growth factor receptor

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