2003•PubMedRequires access

[Inhibiting effect of EGFR monoclonal antibody on proliferation of oral squamous cell carcinoma].

Mingguo Wang, Zhonghe Wang, Hai-sheng Hu

Abstract

OBJECTIVE: To investigate the inhibiting effect of epidermal growth factor receptor (EGFRmAb) on proliferation of oral squamous cell carcinoma (SCC). METHODS: Tca8113 squamous cell carcinoma cell line was treated with different concentration of EGFRmAb. Cell growth curve, clone inhibition rate, cell cycle redistribution and the expression of p27kip1 were analyzed. RESULTS: EGFRmAb inhibited proliferation of oral SCC, leaded to elevation of cell proportion of G1phase cell, decreased the proportion of S phase cell and upregulated the express of p27kip1. CONCLUSION: EGFRmAb inhibited the proliferation of oral SCC, which related with G1 phase arrest of tumor cell.

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Key concepts: Cell growth, Cell cycle, Cell, clone (Java method), Cell culture, Cancer research, Epidermal growth factor receptor, Basal cell