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2010•Strait Pharmaceutical JournalRequires access

Effect of Polygonum cuspidatum extract on CCl_4-induced acute liver injury in mice

Chen Bao

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Abstract

OBJECTIVE To observe the Polygonum cuspidatum extract on CCl4induced acute liver injury in mice.METHODS CCl4-induced acute liver injury model in mice,determine serum alanine aminotransferase(ALT),aspartate aminotransferase(AST),liver superoxide dismutase(SOD) activity and malondialdehyde(MDA) content in liver tissue.RESULTS CCl4-induced acute liver injury model in mice,serum ALT,AST significantly increased,liver SOD activity was significantly reduced,MDA levels were significantly increased(P0.01);Polygonum cuspidatum extrat can significantly reduce serum ALT,AST,obviously improve liver SOD activity and lower MDA content in liver tissue(P0.01).CONCLUSION Polygonum cuspidatum extract has lower liver enzymes and anti-oxidation effect on the CCl4-induced acute liver injury in mice have some protective effect.

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What this paper is about

OBJECTIVE To observe the Polygonum cuspidatum extract on CCl4induced acute liver injury in mice.METHODS CCl4-induced acute liver injury model in mice,determine serum alanine aminotransferase(ALT),aspartate aminotransferase(AST),liver superoxide dismutase(SOD) activity and malondialdehyde(MDA) content in liver tissue.RESULTS CCl4-induced acute liver injury model in mice,serum ALT,AST significantly increased,liver SOD activity was significantly reduced,MDA levels were significantly increased(P0.01);Polygonum cuspidatum extrat can significantly reduce serum ALT,AST,obviously improve liver SOD activity and lower MDA content in liver tissue(P0.01).CONCLUSION Polygonum cuspidatum extract has lower liver enzymes and anti-oxidation effect on the CCl4-induced acute liver injury in mice have some protective effect.

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Available abstract

OBJECTIVE To observe the Polygonum cuspidatum extract on CCl4induced acute liver injury in mice.METHODS CCl4-induced acute liver injury model in mice,determine serum alanine aminotransferase(ALT),aspartate aminotransferase(AST),liver superoxide dismutase(SOD) activity and malondialdehyde(MDA) content in liver tissue.RESULTS CCl4-induced acute liver injury model in mice,serum ALT,AST significantly increased,liver SOD activity was significantly reduced,MDA levels were significantly increased(P0.01);Polygonum cuspidatum extrat can significantly reduce serum ALT,AST,obviously improve liver SOD activity and lower MDA content in liver tissue(P0.01).CONCLUSION Polygonum cuspidatum extract has lower liver enzymes and anti-oxidation effect on the CCl4-induced acute liver injury in mice have some protective effect.

Key concepts: Malondialdehyde, Superoxide dismutase, Liver injury, CCL4, Alanine aminotransferase, Polygonum, Chemistry, Liver tissue

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Effect of Polygonum cuspidatum extract on CCl_4-induced acute liver injury in mice — Research Paper | ScholarLens