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Effect of Polygonum cuspidatum extract on CCl_4-induced acute liver injury in mice

Bo Yang

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Abstract

OBJECTIVE To observe the Polygonum cuspidatum extract on CCl4-induced acute liver injury in mice.METHODS CCl4-induced acute liver injury model in mice,determine serum alanine aminotransferase(ALT),aspartate aminotransferase(AST),liver superoxide dismutase(SOD) activity and malondialdehyde(MDA) content in liver tissue.RESULTS CCl4-induced acute liver injury model in mice,serum ALT,AST was significantly increased,liver SOD activity was significantly decreased,MDA content was significantly higher(P0.01);Polygonum cuspidatum extract significantly decreased serum ALT,AST improve liver SOD activity and lower MDA content in liver tissue(P0.01).CONCLUSION Polygonum cuspidatum extract has the role of reducing enzyme and antioxidant,on CCl4-induced acute liver injury in mice has a protective effect.

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What this paper is about

OBJECTIVE To observe the Polygonum cuspidatum extract on CCl4-induced acute liver injury in mice.METHODS CCl4-induced acute liver injury model in mice,determine serum alanine aminotransferase(ALT),aspartate aminotransferase(AST),liver superoxide dismutase(SOD) activity and malondialdehyde(MDA) content in liver tissue.RESULTS CCl4-induced acute liver injury model in mice,serum ALT,AST was significantly increased,liver SOD activity was significantly decreased,MDA content was significantly higher(P0.01);Polygonum cuspidatum extract significantly decreased serum ALT,AST improve liver SOD activity and lower MDA content in liver tissue(P0.01).CONCLUSION Polygonum cuspidatum extract has the role of reducing enzyme and antioxidant,on CCl4-induced acute liver injury in mice has a protective effect.

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Available abstract

OBJECTIVE To observe the Polygonum cuspidatum extract on CCl4-induced acute liver injury in mice.METHODS CCl4-induced acute liver injury model in mice,determine serum alanine aminotransferase(ALT),aspartate aminotransferase(AST),liver superoxide dismutase(SOD) activity and malondialdehyde(MDA) content in liver tissue.RESULTS CCl4-induced acute liver injury model in mice,serum ALT,AST was significantly increased,liver SOD activity was significantly decreased,MDA content was significantly higher(P0.01);Polygonum cuspidatum extract significantly decreased serum ALT,AST improve liver SOD activity and lower MDA content in liver tissue(P0.01).CONCLUSION Polygonum cuspidatum extract has the role of reducing enzyme and antioxidant,on CCl4-induced acute liver injury in mice has a protective effect.

Key concepts: Malondialdehyde, Superoxide dismutase, CCL4, Liver injury, Alanine aminotransferase, Chemistry, Liver tissue, Antioxidant

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Effect of Polygonum cuspidatum extract on CCl_4-induced acute liver injury in mice — Research Paper | ScholarLens