2021•Unpublished venueOpen access

Author response: Human ORC/MCM density is low in active genes and correlates with replication time but does not delimit initiation zones

Nina Kirstein, Alexander Buschle, Xia Wu, Stefan Krebs, Helmut Blum, Elisabeth Kremmer, Ina Vorberg, Wolfgang Hammerschmidt, Laurent Lacroix, Olivier Hyrien, Benjamin Audit, Aloys Schepers

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Abstract

Replication origins are established throughout the genome with the exception of transcribed genes, and the local chromatin composition likely modulates the density of ORC and MCM as well as origin activation.

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Key concepts: Minichromosome maintenance, Origin recognition complex, Licensing factor, DNA replication factor CDT1, Pre-replication complex, Origin of replication, Biology, DNA replication