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2020•Unpublished venueOpen access

Decision letter: Human ORC/MCM density is low in active genes and correlates with replication time but does not delimit initiation zones

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Abstract

Replication origins are established throughout the genome with the exception of transcribed genes, and the local chromatin composition likely modulates the density of ORC and MCM as well as origin activation.

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What this paper is about

Replication origins are established throughout the genome with the exception of transcribed genes, and the local chromatin composition likely modulates the density of ORC and MCM as well as origin activation.

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Available abstract

Replication origins are established throughout the genome with the exception of transcribed genes, and the local chromatin composition likely modulates the density of ORC and MCM as well as origin activation.

Key concepts: Minichromosome maintenance, Origin recognition complex, Licensing factor, Pre-replication complex, DNA replication factor CDT1, Origin of replication, Biology, DNA replication

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Decision letter: Human ORC/MCM density is low in active genes and correlates with replication time but does not delimit initiation zones — Research Paper | ScholarLens