2020•PubMedRequires access

[Effect of thyroxine on the expression of HIF-1α after aneurysmal subarachnoid hemorrhage in rat brain and its mechanism].

Hui Ran, Hao Yin, Chuangxi Liu, Guoqiang Han, Fang-you Gao, Hong-Bin Shen, Hang Fu, Xiao-Zhong Xu, Tao Li, Jun Ma

Abstract

The expression of HIF-1α protein in the brain of rats after aneurysm subarachnoid hemorrhage can be upregulated by T4 replacement therapy, which may by activating the signal pathway of inositol triphosphate kinase / protein kinase B (PI3K/Akt). Finally, apoptosis index was decreased, the rat behavior was improved and the brain was protected.

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Available abstract

Key concepts: Subarachnoid hemorrhage, Medicine, Anesthesia, Subarachnoid space, TUNEL assay, Immunohistochemistry, Apoptosis, Internal medicine