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INFLUENCE OF ALUMINIUM ON T HE CONCENTRATION OF PHOSPHORUS AND ADENYL NUCLEOTIDES IN WHITE RAT ERYTHROCYTES

B. Kavaldzhieva, P. Nikolova

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Abstract

The experiment covered 126 white male rats divided into two groups: 70 poisoned rats (group one) and 56 control ones (group two). Animals from the first group were perorally introduced I per cent of water solution of AlCl3 in a dosis of 3 mg Al3+/kg body mass daily for 40 days. The concentrations of inorganic phosphorus and adenyl nucleotides such as AMP, ADP and ATP in rat erythrocytes were determined on the 5th, 10th, 15th, 20th, 30th, and 40th day of trial. An elevation of ATP concentration tending towards a shift to the left of ATP/ADP balance during the second half of the experiment was established. Inorganic phosphorus reduced significantly during the whole trial. These alterations testify to disturbed processes of erythrocytic energy Metabolism.

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What this paper is about

The experiment covered 126 white male rats divided into two groups: 70 poisoned rats (group one) and 56 control ones (group two). Animals from the first group were perorally introduced I per cent of water solution of AlCl3 in a dosis of 3 mg Al3+/kg body mass daily for 40 days. The concentrations of inorganic phosphorus and adenyl nucleotides such as AMP, ADP and ATP in rat erythrocytes were determined on the 5th, 10th, 15th, 20th, 30th, and 40th day of trial. An elevation of ATP concentration tending towards a shift to the left of ATP/ADP balance during the second half of the experiment was established. Inorganic phosphorus reduced significantly during the whole trial. These alterations testify to disturbed processes of erythrocytic energy Metabolism.

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Available abstract

The experiment covered 126 white male rats divided into two groups: 70 poisoned rats (group one) and 56 control ones (group two). Animals from the first group were perorally introduced I per cent of water solution of AlCl3 in a dosis of 3 mg Al3+/kg body mass daily for 40 days. The concentrations of inorganic phosphorus and adenyl nucleotides such as AMP, ADP and ATP in rat erythrocytes were determined on the 5th, 10th, 15th, 20th, 30th, and 40th day of trial. An elevation of ATP concentration tending towards a shift to the left of ATP/ADP balance during the second half of the experiment was established. Inorganic phosphorus reduced significantly during the whole trial. These alterations testify to disturbed processes of erythrocytic energy Metabolism.

Key concepts: Nucleotide, Phosphorus, Chemistry, Animal science, Adenine nucleotide, Internal medicine, Metabolism, White Phosphorus

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INFLUENCE OF ALUMINIUM ON T HE CONCENTRATION OF PHOSPHORUS AND ADENYL NUCLEOTIDES IN WHITE RAT ERYTHROCYTES — Research Paper | ScholarLens