2021•Infection and ImmunityOpen access
Host Genome-Wide Association Study of Infant Susceptibility toShigella-Associated Diarrhea
Dylan Duchen, Rashidul Haque, Laura Chen, Genevieve L. Wojcik, Poonum Korpe, Uma Nayak, Alexander J. Mentzer, Beth D. Kirkpatrick, William A. Petri, Priya Duggal
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Abstract
Shigellais a leading cause of moderate-to-severe diarrhea globally and the causative agent of shigellosis and bacillary dysentery. Associated with 80 to 165 million cases of diarrhea and >13% of diarrheal deaths, in many regions,Shigellaexposure is ubiquitous while infection is heterogenous.