ScholarLens Back to search
1992•˜Die œpharmazeutische Industrie/Pharmazeutische IndustrieRequires access

Evaluation of the tabletting properties of a new excipient for direct compression

Jacqueline A. Plaizier-vercammen, H. Van den Bossche

Open publisher page 4 citations

Abstract

Ludipress ® seems to be a very good excipient for direct compression. Good tablets could be prepared at low compression forces. Addition of a glidant was necessary. Mixing time of glidants, e.g. magnesium stearate and Pruv (sodium stearyl fumarate) had almost no effect on crushing strength. Pruv showed an advantage above the use of magnesium stearate in that the disintegration time was almost not influenced. The binding capacity of Ludipress was higher in comparison with microcrystalline cellulose

About this research paper

What this paper is about

Ludipress ® seems to be a very good excipient for direct compression. Good tablets could be prepared at low compression forces. Addition of a glidant was necessary. Mixing time of glidants, e.g. magnesium stearate and Pruv (sodium stearyl fumarate) had almost no effect on crushing strength. Pruv showed an advantage above the use of magnesium stearate in that the disintegration time was almost not influenced. The binding capacity of Ludipress was higher in comparison with microcrystalline cellulose

Why it matters

OpenAlex reports 4 citations for this work. Citation counts describe recorded attention and do not establish research quality.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

Ludipress ® seems to be a very good excipient for direct compression. Good tablets could be prepared at low compression forces. Addition of a glidant was necessary. Mixing time of glidants, e.g. magnesium stearate and Pruv (sodium stearyl fumarate) had almost no effect on crushing strength. Pruv showed an advantage above the use of magnesium stearate in that the disintegration time was almost not influenced. The binding capacity of Ludipress was higher in comparison with microcrystalline cellulose

Key concepts: Magnesium stearate, Excipient, Microcrystalline cellulose, Compression (physics), Pharmaceutical technology, Materials science, Magnesium, Mixing (physics)

Related papers

Related paper 1Related paper 2Related paper 3
Back to paper searchBrowse research topicsOriginal source
Evaluation of the tabletting properties of a new excipient for direct compression — Research Paper | ScholarLens