2007•Journal of Biological ChemistryOpen access
Proteolytic activities of human ADAMTS-5.
Christi M. Gendron, Masahide Kashiwagi, Ngee Han Lim, Jan J. Enghild, Ida B. Thøgersen, Clare Hughes, Bruce Caterson, Hideaki Nagase
Open full text 4 citations
Abstract
Proteolytic Activities of Human ADAMTS-5: COMPARATIVE STUDIES WITH ADAMTS-4Journal of Biological ChemistryVol. 282Issue 25PreviewAggrecanases have been characterized as proteinases that cleave the Glu373-Ala374 bond of the aggrecan core protein, and they are multidomain metalloproteinases belonging to the ADAMTS (adamalysin with thrombospondin type 1 motifs) family. The first aggrecanases discovered were ADAMTS-4 (aggrecanase 1) and ADAMTS-5 (aggrecanase 2). They contain a zinc catalytic domain followed by non-catalytic ancillary domains, including a disintegrin domain, a thrombospondin domain, a cysteine-rich domain, and a spacer domain. Full-Text PDF Open Access PAGE 18299: In the last line of the legend to Table I: “ND, not determined” should read “ND, not detectable.”