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The Research of A Disintegrin-like and Metalloproteinase with Thrombospondin Type 1 Motifs

Jun Zhang

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Abstract

A disintegrin-like and metalloproteinase with thrombospondin type 1 motifs(ADAMTS),which is a new family of secreted zinc-dependent metaloproteases.The resent studies of ADAMTS's structure showed that the hypermethylation of TSP impacted the stabilization of oncogenes or tumor suppressor genes,or mRNA and that domain was related with the proteolysis of aggrecan in human osteoarthritic.CUB domain is associated with vWF-cleaving activity which played an important part in thrombotic thrombocytopenia purpura.These advances provide a new way of thought in diagnosis and treatment in the future.

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What this paper is about

A disintegrin-like and metalloproteinase with thrombospondin type 1 motifs(ADAMTS),which is a new family of secreted zinc-dependent metaloproteases.The resent studies of ADAMTS's structure showed that the hypermethylation of TSP impacted the stabilization of oncogenes or tumor suppressor genes,or mRNA and that domain was related with the proteolysis of aggrecan in human osteoarthritic.CUB domain is associated with vWF-cleaving activity which played an important part in thrombotic thrombocytopenia purpura.These advances provide a new way of thought in diagnosis and treatment in the future.

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Available abstract

A disintegrin-like and metalloproteinase with thrombospondin type 1 motifs(ADAMTS),which is a new family of secreted zinc-dependent metaloproteases.The resent studies of ADAMTS's structure showed that the hypermethylation of TSP impacted the stabilization of oncogenes or tumor suppressor genes,or mRNA and that domain was related with the proteolysis of aggrecan in human osteoarthritic.CUB domain is associated with vWF-cleaving activity which played an important part in thrombotic thrombocytopenia purpura.These advances provide a new way of thought in diagnosis and treatment in the future.

Key concepts: Thrombospondin, Disintegrin, ADAMTS, Metalloproteinase, Aggrecan, Proteolysis, ADAMTS13, Matrix metalloproteinase

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