Acquired rare recurrent EGFR mutations as mechanisms of resistance to Osimertinib in lung cancer and in silico structural modelling.
Lin Lin, Qiang Lu, Ran Cao, Qiuxiang Ou, Yutong Ma, Hua Bao, Xue Shen Wu, Yang Shao, Zhaoxia Wang, Bo Shen
Abstract
Lin Lin, Qiang Lu, Ran Cao, Qiuxiang Ou, Yutong Ma, Hua Bao, Xue Shen Wu, Yang Shao, Zhaoxia Wang, Bo Shen
Abstract
-mutated lung cancer. We identified a collection of coexistent EGFR rare mutations and provided possible guidance for those patients who progressed on the first-line treatment of Osimertinib.
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-mutated lung cancer. We identified a collection of coexistent EGFR rare mutations and provided possible guidance for those patients who progressed on the first-line treatment of Osimertinib.
Key concepts: Osimertinib, Lung cancer, Gefitinib, Medicine, Cancer research, In silico, Oncology, Mutation