SOLUBILITY AND DISSOLUTION RATE STUDY OF GLIBENCLAMIDE USING SOLVENT EVAPORATION METHOD

Purpose: Enhancement of the solubility and dissolution rate of poorly water soluble Glibenclamide using solid dispersion with PVP K-90, PVP K-30 and Eudragit RS-100 by solvent evaporation technique. Methods: The prepared solid dispersions were evaluated for percentage yield, drug content, solubility, dissolution and other physicochemical properties. The solid dispersions were prepared by conventional solid dispersions technique shows improvement in solubility, dissolution and other physicochemical properties comparative to pure Glibenclamide (GBM). The prepared solid dispersions were characterized using powder XRD, DSC, SEM and FTIR techniques. The prepared solid dispersions exhibit enhanced release profiles of pharmaceutical agent due to the increased wetting properties and surface of drug available for dissolution. A comparative evaluation of the dissolution of Glibenclamide solid dispersions, pure drug and marketed formulation (tablet) was carried out. Results: Dissolution of Glibenclamide improved significantly in solid dispersions as compared to pure drug. IR spectroscopy and DSC showed no change in crystal structure of Glibenclamide. Conclusions: In conclusion, the results of this work suggest that solvent evaporation technique is a useful technique to enhance the solubility and dissolution rate of poorly water-soluble.