ENHANCEMENT OF DISSOLUTION RATE OF GLIBENCLAMIDE BY SOLID DISPERSION TECHNOLOGY

The aim of the study is to prepare solid dispersion of Glibenclamide using different carriers such as PEG 6000, Polyvinyl pyrolidine (PVP) and Poloxamers in different ratios (1:1, 1:2, 1:3, 1:4 and 1:5) by Solvent Evaporation method. Drug carrier interactions were analysed by X‐ray diffraction and Infra‐Red Spectroscopy. Dissolution studies using the USP paddle method were performed for all solid dispersions. All solid dispersions showed increased dissolution rate as compared to pure Glibenclamide and PVP was found to be better than PEG and Poloxamer. The tablets were formulated using solid dispersion of Glibenclamide containing PVP as carrier. The tablets containing solid dispersion exhibited better dissolution profile than commercial tablets. Thus solid dispers ion technique can be successfully used for improvement of dissolution of Glibenclamide.