Improvement of institutions for dispensary observation of children from the risk group in phthisiology

Introduction. Tuberculosis in Russia is one of the primary problems of epidemiology and public health. The purpose: to analyze the epidemic situation of tuberculosis in high-risk groups of children and adolescents in the Tyumen region of Russia. Material and methods. Were analyzed the annual reporting forms No. 33 «Information about patients with tuberculosis» for 2014-2018 in the Tyumen region. Results. According to our research, research materials in the region, WHO recommendations for eliminating tuberculosis by 2035 the need to develop new approaches and practical recommendations for clinical dispensary observation of children with altered tuberculin sensitivity is justified. Discussion. The epidemic situation among children with altered tuberculin sensitivity by 2018 in the districts of the Tyumen region is characterizing by its heterogeneity. In some districts of the region, the number of children with a turn of tuberculin reactions remains high or continues to increase. Such trends can be associated with the incidence of tuberculosis and the presence of patients with open forms of respiratory tuberculosis in these areas. Conclusion. To improve the efficiency of preventing the development of active tuberculosis in Russian children in 2010, a mathematical model of immune response developed in the Tyumen Region based on the study of immunological indices in groups of children with high sensitivity and hyperresponsiveness to the Mantoux tests 2TE samples. The model can be successfully used for diagnostics and assess the characteristics of the course of tuberculosis infection.