SYNTHESIS AND ANTHELMINTIC ACTIVITY STUDY OF BENZIMIDAZOLE DERIVATIVES

The benzimidazole nucleus has a significant importance in medicinal chemistry and many benzimidazole containing compounds exhibit important biological activities. In the present study, synthesis, spectral studies and biological evaluation of three benzimidazole derivatives were investigated. The structures of the synthesized compounds were characterized by IR, 1H-NMR, 13C-NMR, Mass spectroscopy and CHN elemental analyzer and the synthesized compounds were screened for anthelmintic activity by using Indian earthworms, Pheretima posthuma. Albendazole 25mg/ml had taken as a standard drug for the experiment. 25, 50 and 100mg/ml concentrations of the three synthesized compounds (1a – 1c) had taken as tests sample.