Comparative Study of Lisinopril Versus Telmisartan Effects on Oxidative Stress in Diabetic Type 2 Hypertensive Patients

The present study was performed in order to compare the efficacy of lisinopril against telmisartan on oxidative stress represented by serum malondialdehyde (MDA) and total antioxidants status (TAS) in already diabetic newly diagnosed hypertensive patients. It was organized according to a randomized controlled comparative trial during the period of the study from November 2010 to June 2011. The current study included 82 patients, 43 took lisinopril (5 mg/day), 39 enrolled with telmisartan (40 mg/day). In addition to 48 apparently healthy persons taken as controls. Serum levels of MDA and TAS were estimated before and after one month of therapy for patients, and at baseline only for controls. In the present study type 2 diabetic hypertensive patients revealed a significant rise in serum MDA and TAS at baseline stage, however, one month monotherapy with either lisinopril or telmisartan result in a significant improvement in both above parameters. The final conclusion of the study was that both lisinopril and telmisartan are able to subside oxidative stress in diabetic hypertensive patients.