The effect of age on prediction of concurrent endometrial cancer in patients with atypical endometrial hyperplasia

Purpose: To evaluate the effect of age on prediction of concurrent endometrial cancer (EC) in patients with atypical endometrial hyperplasia (AEH). Materials and Methods: Medical data of 176 patients who were diagnosed with atypical endometrial hyperplasia and underwent surgical treatment enrolled the study group. Clinicopathological features, preoperative and postoperative information were collected. The age distrubition for patients with atypical endometrial hyperplasia and endometrial cancer were examined and stratified according to five-year age increments. Results: Concurrent endometrial cancer was detected in 35(19.8%) patients. atypical endometrial hyperplasia and lower grade hyperplasia (simple or complex) was found in 82(46.5%) and 27(15.3%) patients, respectively. Endometrial cancer was most frequently seen in 51-60 age group. Endometrial cancer in final pathology significantly increased (p = 0,0005) after the age of 53 with sensitivity of 65.52% and 76.67%. Conclusion: Endometrial cancer increases significantly after the age of 53 in patients with atypical endometrial hyperplasia. Based on this study it is recommended that clinicians shoud be aware of this knowledge while informing patients and planning treatment.