2020Encyclopedia of Inorganic and Bioinorganic ChemistryRequires access

Platinum‐Based Anticancer Drugs

Yan‐Cheng Liu, Jessica J. Miller

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Abstract

Abstract In this article, the new developments on the platinum‐based anticancer drugs mainly in the past decade were remarked and discussed. These include the new research progress and insights on the classical platinum drugs, such as cisplatin and oxaliplatin, as well as the recent research progress on those nonclassical platinum‐based drugs. Especially, we focused on the emerging studies on the polynuclear platinum complexes, platinum(IV) complexes, and the photodynamic therapy and nanocarrier systems of these new types of platinum complexes. We have tried to select the most representative ones to be emphasized so that the most significant research progress of the platinum drugs may be shown and reported. This will inspire more scientists to develop better and more promising platinum‐based drugs based on these research findings in the future.

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What this paper is about

Abstract In this article, the new developments on the platinum‐based anticancer drugs mainly in the past decade were remarked and discussed. These include the new research progress and insights on the classical platinum drugs, such as cisplatin and oxaliplatin, as well as the recent research progress on those nonclassical platinum‐based drugs. Especially, we focused on the emerging studies on the polynuclear platinum complexes, platinum(IV) complexes, and the photodynamic therapy and nanocarrier systems of these new types of platinum complexes. We have tried to select the most representative ones to be emphasized so that the most significant research progress of the platinum drugs may be shown and reported. This will inspire more scientists to develop better and more promising platinum‐based drugs based on these research findings in the future.

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Available abstract

Abstract In this article, the new developments on the platinum‐based anticancer drugs mainly in the past decade were remarked and discussed. These include the new research progress and insights on the classical platinum drugs, such as cisplatin and oxaliplatin, as well as the recent research progress on those nonclassical platinum‐based drugs. Especially, we focused on the emerging studies on the polynuclear platinum complexes, platinum(IV) complexes, and the photodynamic therapy and nanocarrier systems of these new types of platinum complexes. We have tried to select the most representative ones to be emphasized so that the most significant research progress of the platinum drugs may be shown and reported. This will inspire more scientists to develop better and more promising platinum‐based drugs based on these research findings in the future.

Key concepts: Platinum, Oxaliplatin, Cisplatin, Nanocarriers, Platinum compounds, Pharmacology, Nanotechnology, Combinatorial chemistry

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