AGE-RELATED CHARACTERISTIC OF C-FOS PROTEIN EXPRESSION IN THE NEURONS OF HYPOTHALAMIC SUPRAOPTIC NUCLEUS IN MALE WISTAR RATS

Taking into account the important role of oxytocin- and vasopressinergic hypothalamic neurosecretory systems in the regulation of many of organism’s physiological functions the alterations of transcription factor c-Fos expression in it can be supposed. The rate of c-Fos expression may vary in the process of animals’ development; it’s variability can be considered to be an index of hypothamus’ functional activity. The aim of research was to study peculiarities of c-Fos transcription factor expression in hypothalamic supraoptic nucleus in male Wistar rats of different age groups, to define correlative relations of protein expression parameters with the level of the analyzed hormones. The results of research demonstrate that the rate of manifestation of transcription factor c-Fos protein expression in the neurons of hypothalamic supraoptic nucleus is age-dependent; the patterns of c-Fos protein expression intensify in the period of puberty. Positive correlative relations are established between: the area of immunoreactive material to c-Fos protein in the neurons with the level of leptin, epiniphrine and corticosterone; c-Fos protein concentration and content in the immunoreactive material in the neurons with the level of insulin and epinephrine.