2013•Guoji yiyao weisheng daobaoRequires access
Observation on curative effect of Montelukast in treating Henoch-Schonlein purpura in children
Xie He, Guicai Li, Shu-zhuang Wu, Pengpeng Wang, Bin Huang, Yue-mei Qian
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Abstract
Objective To investigate the clinical effects of Montelukast in treating Henoch-Schonlein purpura children.Methods 120 children with Henoch-Schonlein purpura were randomly divided into two groups.The control group was treated with conventional medication.The treatment group was treated with montelukast sodium (2 ～ 6 year-old given 4 mg/d,6 ～ 13 year-old given 5 mg/d,per os before sleep) in addition.The clinical effects of the two groups were compared.Results The cure rate of treatment group was obviously higher than that of the conventional group (P ＜ 0.05).The clinical effect in the control group:excellent 40 cases,utility 5 cases,ineffective 15 cases; the clinical effect in the treatment group:excellent 50 cases,utility 9 cases,ineffective 1 case.Conclusion There is a close relationship between leukotriene receptor expression in Henoch-Schonlein purpura,leukotriene receptor antagonist is effective in treatment of Henoch-Schonlein purpura,with no obvious adverse reaction.
Key words:
Leukotriene; Henoch-Schonlein purpura; Montelukast