2001•中国行为医学科学Requires access
Plasmatic arginine Vasopressin(AVP) concentration in schizophrenic patients
余海鹰, 刘龙林, 高志勤, 张书友, 汪广剑, 薛蕴庄, 陈方斌, 范庆祝, 高柏良
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Abstract
Objective To explore the changes of plasmatic AVP in schizophernic patients. Methods Plasmatic AVP concentration was determined with radioimmunoassay in 38 Schizophrenic Patients and 22 normal controls. Result Compared with normal controls, plasmatic AVP concentration in schizophrenic patients was significant decreased （t=9.59, P＜0.01）.There were significant difference in plasmatic AVP of patients before and after clozapine treatment（t=2.37，P＜0.05）;No significant different was found in patients before and after chlorpromazine treatment(t=0.85, P＞0.05).Conclusions The results suggest that there are abnormal metabolism in plasmatic AVP of schizophrenic patients. The metabolism of AVP in schizophrenic patients may be influenced by treatment of some psychotropic drugs, such as clozapine.