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Determination of plasma arginine vasopressin(AVP) level with radioimmunoassay in schizophrenia

Liu Long

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Abstract

Objectives:To study the changes of plasma arginine vasopressin level in schizophrenia patients. Methods:Plasma AVP level was determined with radioimmunoassay in 38 schizophrenia patients and 22 normal controls. Results: Plasma AVP level was significantly decreased( t =9.59, P 0.01) in schizophrenia patients than normal controls. Patients not cured with clozapine 4 weeks later had lower AVP level than those who were cured( t =2.21, P 0.05). Conclusions: AVP level was depressed and clozapine might influence AVP metabolism in schizophrenia.

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Objectives:To study the changes of plasma arginine vasopressin level in schizophrenia patients. Methods:Plasma AVP level was determined with radioimmunoassay in 38 schizophrenia patients and 22 normal controls. Results: Plasma AVP level was significantly decreased( t =9.59, P 0.01) in schizophrenia patients than normal controls. Patients not cured with clozapine 4 weeks later had lower AVP level than those who were cured( t =2.21, P 0.05). Conclusions: AVP level was depressed and clozapine might influence AVP metabolism in schizophrenia.

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Available abstract

Objectives:To study the changes of plasma arginine vasopressin level in schizophrenia patients. Methods:Plasma AVP level was determined with radioimmunoassay in 38 schizophrenia patients and 22 normal controls. Results: Plasma AVP level was significantly decreased( t =9.59, P 0.01) in schizophrenia patients than normal controls. Patients not cured with clozapine 4 weeks later had lower AVP level than those who were cured( t =2.21, P 0.05). Conclusions: AVP level was depressed and clozapine might influence AVP metabolism in schizophrenia.

Key concepts: Vasopressin, Radioimmunoassay, Internal medicine, Arginine, Schizophrenia (object-oriented programming), Endocrinology, Clozapine, Plasma levels

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