Effect of bundle comprehensive brain protection treatments on cerebral oxygen metabolism, endothelin and intracranial pressure of patients with severe craniocerebral trauma

Objective To explore how the bundle comprehensive brain protection treatments affects cerebral oxygen metabolism, endothelial cell function and intracranial pressure of patients with severe craniocerebral trauma. Methods One hundred and twenty patients with severe craniocerebral trauma were selected from January 2014 to November 2016 in our hospital. The patients were randomly divided into control group and observation group (n=60). Patients from the control group were given normal treatment; whilst patients from the observation group were additionally treated with bundle comprehensive brain protection treatments. The cerebral oxygen metabolism levels (jugular bulb venous oxygen saturation [SjVO2], cerebral extraction of oxygen [CEO2] and arteriovenous oxygen difference [AVDO2]), endothelin (ET) level and intracranial pressure (ICP) were calculated and compared before and after treatment. Results The levels of SjVO2, CEO2 and AVDO2, and ET and ICP levels showed no significant differences between the obvseration group and control group before treatment (P>0.05). After treatment, the levels of SjVO2, CEO2 and AVDO2 in the observation group were significantly higher than those in the control group (P<0.05); as compared with those in the control group, the ET and ICP levels in the observation group were significantly decreased (P<0.05). Conclusion The bundle comprehensive brain protection treatments could improve cerebral oxygen metabolism and endothelial function, and decrease the ET and ICP levels of patients with severe craniocerebral trauma, which has important value in clinical practice. Key words: Severe traumatic brain injury; Bundle; Comprehensive brain protection