Influence of Mild Hypothermia on Cerebral Oxygen Metabolism and Prognosis of Patients with Severe Head Injury

Objective To study the effect of mild hypothermia on cerebral oxygen metabolism and patients prognostic.Methods Fifty-three patients after surgery for serious head injury were studied and randomly divided into hypothermic groups and normal temperature groups.ICP,burst artery blood gas analysis,jugular bulb for gas analysis,jugular bulb blood oxygen saturation(SjvO2),cerebral arterial-venous oxygen content difference(AVDO2) were accessed and scored,and cerebral extraction of oxygen(CEO2) were calculated in all the patients.Results From the first post injury day SjvO2 increased and CEO2 and AVDO2 decreased in hypothermic groups.There were significant differences between hypothermic groups and normal temperature groups(all P0.01).ICP of hypothermic group is lower than that of normal temperature group(P0.01).There were significant difference in death rate between hypothermic group and normal temperature group(P0.01).Conclusion In the earlier period of patients with serious head injury,mild hypothermia could significantly decrease cerebral oxygen metabolism,increase the tolerance to cerebral ischemia,alleviate cephaledema,descend intracranial hypertension and improve patients prognosis.