Role of nuclear factor-κB in brain ischemic preconditioning

Brain ischemic conditioning （BIP） can improve the tolerance to ischemic injury in the brain. Nuclear factor-κB （NF-κB） is an important transcriptional regulatory factor.It presents in all types of cells in the nerous system. Studies have suggested that BIP may exert neuroprotective effects by mediating NF-κB through a series of cascade reactions. This may provide a new therapeutic strategy for BIP in the prevention and treatment of ischemic cerebrovascular disease in clinical practice. Key words: NF-κB;  Brain ischemia;  Ischemic preconditioning;  Neuroprotective agents