2018•Int J Cerebrovasc DisRequires access

Neuroprotective effect of lipopolysaccharide preconditioning on cerebral ischemia and its mechanism

Zengli Wang

Abstract

Cerebral ischemic preconditioning can make the brain tissue resistant to subsequent ischemic injury, i. e. ischemic tolerance, thereby reducing ischemia-reperfusion injury. A large number of studies have shown that lipopolysaccharide preconditioning can exert neuroprotective effects against cerebral ischemic injury by initiating endogenous protective mechanisms. This article reviews the cellular and molecular mechanisms of lipopolysaccharide preconditioning induced cerebral ischemic tolerance. Key words: Brain Ischemia; Reperfusion Injury; Ischemic Preconditioning; Lipopolysaccharides; Neuroprotective Agents

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Key concepts: Neuroprotection, Ischemia, Ischemic preconditioning, Medicine, Lipopolysaccharide, Anesthesia, Ischemic injury, Brain ischemia