Clinical pathological analysis on 57 patients of epilepsy with malformations of cortical development

Objective To approach the clinical pathological characteristics of epilepsy with malformations of cortical development(MCD).Method The clinical information and pathologic characteristic were studied retrospectively in 57 cases of epilepsy with MCD.Results Among the total operated epilepsy cases,the percentage of epilepsy with MCD was 43%(57/132).The ratio between man and woman was 3.8 to 1.0.The average age was 25.4 years old.The average history of epileptic attack was 10.4 years.Among the 57 cases of epilepsy with MCD,there were 8 cases in major disruption;8 cases in microdygenesis(MD);41 cases in focal cortical dysplasia(FCD).In FCD,there were 13 cases in FCD Ⅰ A;15 cases in FCD Ⅰ B;7 cases in FCDⅡA;6 cases in FCDⅡB.Further more,22 cases were accompanied with hippocampal sclerosis;1 case of FCDⅡB with dysembryoplastic neuroepithelial tumors(DNT);1 case of FCDⅡB with gangliogiiomas(GGs).Conclusions There is a close relationship between MCD and epilepsy:FCD Ⅰ type is the most common subtype of MCD;many cases have hippocampal sclerosis. Key words: Epilepsy; Focal cortical dysplasia; Pathology