Evaluation of the diastolic function in patients with hypertrophic cardiomyopathy by tissue Doppler imaging

Objective To investigate the diagnostic value of tissue Doppler imaging(TDI)for diastolic function in hypertrophic cardiomyopathy(HCM).Methods Sixty patients with HCM and thirty age-matched control were enrolled in this study.Parameters of conventional echocardiogram and TDI were compared.Results In the HCM group,left atrial diameter,left atrial area,thickness of inter-ventricular septum(IVS),ratio of IVS to left ventricular posterior wall(IVS/LVPW),E/Em and left ventricular filling pressure were statistically higher than those of control group(P<0.01,respectively),Em was significantly lower(P<0.01).There was no statistical difference on E/A between HCM and control group(P=0.67).E/Em was correlated positively with left atrial diameter and area in the HCM group(r=0.331,P=0.017;r=0.325,P=0.019,respectively).However,E/A had no statistical correlation with left atrial diameter and area(r=0.205,P=0.142;r=0.255,P=0.066,respectively).Conclusions Compared with the conventional Doppler ecbocardiogram,the parameters of TDI(Em,E/Em)were more sensitive in evaluation of diastolic function in HCM patients. Key words: Echocardiography; Doppler; Cardiomyopathy,hypertrophic; Ventricular function,left