Effects of abnormal glucose metabolism during pregnancy on fetal body mass and incidence of neonatal complications

Objective To investigate the effects of abnormal glucose tolerance during pregnancy on the incidence of fetal body mass and neonatal complications.Methods Oral 50g glucose challenge test (GCT)was done in 2502 cases of pregnant women,156 cases of abnormal 75g oral glucose tolerance retest (OGTT),diagnosed with gestational diabetes mellitus (GDM) in 86 cases,gestational impaired glucose tolerance (GIGT) in 70 cases,and 300 cases of the control group,then we compared the incidence of fetal students body mass,neonatal complications.Results Fetal body mass of GIGT and GDM groups was large for gestational age and fetal macrosomia,significantly higher than that of the control group,the appropriate for gestational age at birth rate was significantly lower than that of the control group,there was statistical significant difference (P ＜ 0.01); small for gestational age infants birth rate was also higher than that of the control group (P ＜ 0.05); GIGT and GDM groups of pregnant women neonatal hypoglycemia,hyperbilirubinemia and in birth injury incidence was significantly higher than that in the control group,there was significant difference (P ＜ 0.01); concurrent premature,asphyxia morbidity were igher than those of the control group,there was statistical significant difference (P ＜ 0.05).Conclusion In clinical practice it is very necessary to detect glucose metabolism with anomaly detection and diagnosis system for all pregnant women,normal glucose metabolism treatment should be standardized and monitored; neonates delivered by all pregnant women with abnormal glucose metabolism should be given timely monitoring of blood glucose,complications and timely intervention. Key words: Impaired glucose tolerance;  Pregnancy;  Fetus;  Body weight;  Newborn