The Effect of Gestational Abnormal Metabolism of Glucose on Outcome of Pregnancy

To understand the adverse effect of gestational abnormal metabolism of glucose on outcome of pregnancy. 378 pregnant women at gestational age of 24～34 weeks were screened with the 50 g glucose challenge test (GCT), positive reaction subjects further took oral 75 g glucose tolerance test (OGTT). They were divided into the following groups: group of 342 pregnant women with normal response to 50 g GCT and 75 g OGTT, group of 12 pregnant women with gestational diabetes mellitus (GDM) and group of 24 pregnant women with gestational impaired glucose tolerance (GIGT). The pregnant outcome were compared in these three groups. The frequency of GDM and GIGT was 3 1% and 6 3% respectively. The incidence of premature delivery, diabetic ketoacidosis and hyperbilrubinemia of neonate in the GDM group were higher than that in the group with normal gestational glucose metabolism (P0 05), the incidences of pregnancy induced hypertension, polyhydramnios, fetal macrosomia, neonatal hypoglycemia, and rate of cesarean section in the groups of GDM and GIGT were higher than that in the control group (P0 05). There were no significant differences in the incidences of the above mentioned complications between the groups of GDM and GIGT. [Conclusion] Abnormal metabolism of glucose in pregnancy can increase the morbidity of mothers and neonates. It is very important to make early detection, early diagnosis and treatment for abnormality of glucose metabolism during pregnancy.