Effects of ambroxol hydrochloride injection combined with pulmonary surfactant on the improvement of arterial blood gas index and the time of mechanical ventilation in neonates with respiratory distress syndrome

Objective To investigate the effects of ambroxol hydrochloride injection combined with pulmonary surfactant(PS) on the improvement of arterial blood gas index and the time of mechanical ventilation in neonates with respiratory distress syndrome(NRDS). Methods 82 children with NRDS were selected, and they were randomly divided into two groups according to the digital table, 41 cases in each group.The control group received 100mg/kg PS inhalation, and the study group received intravenous injection of 7.5mg/kg ambroxol hydrochloride + 100mg/kg PS inhalation.The changes of arterial blood gas index[PaO2, arterial carbon dioxide pressure (PaCO2), pH value], mechanical ventilation time, oxygen supply time and hospitalization time were statistically compared between the two groups. Results The PaO2[(89.38±4.72)mmHg]and pH value (7.40±0.02) of the study group were higher than those of the control group[(66.42±5.58)mmHg, (7.32±0.04)]at 12h after treatment, while PaCO2[(29.04±4.63)mmHg]was lower than that in the control group[(35.38±5.67)mmHg], and the differences were statistically significant(t=20.115, 11.454, 5.545, all P=0.000). The hospitalization time, oxygen supply time and mechanical ventilation time of the study group were lower than those of the control group[(11.10±3.47)d vs.(18.61±8.72)d, (7.49±5.31)d vs.(14.32±11.61)d, (56.21±11.78)h vs.(78.22±18.31)h], and the differences were statistically significant(t=5.123, 3.425, 6.473, all P=0.000). Conclusion Ambroxol hydrochloride injection combined with PS can improve the arterial blood gas index in children with NRDS and shorten the time of mechanical ventilation, hospitalization and oxygen supply. Key words: Respiratory distress syndrome, newborn; Pulmonary surfactant-associated proteins; Ambroxol hydrochloride injection