The clinical features and surgical treatment of medically refractory epilepsy caused by temporal lobe gangliogliomas

Objective Summarizes the clinical features,the method of epileptic focus localization,and the surgical treatment and prognosis of secondary epilepsy caused by the temporal lobe ganglilglioma,Methods 24 cases temporal lobe ganglioglioma patients who received surgical treatment for refractory epiclepsy in Tsinghua University Yuquan Hospital,during SEP 2008-SEP 2011 and confirmed by pathology were analysis retrospectively.Results The diagnosis of temporal lobe epilepsy were comfirmed in 24 cases of patients base on the magnetic resonance.All of these 24 patients received operation of resection with ECOG monitoring,and 4 cases received selective amygdal and hippocampus resection.17 cases received anterior temporal lobe and hippocampus resection.3 cases received anterior temporal lobe resection which including lessions.All patients' results were good,they were followed up for 1 year-4years.Engle Ⅰ 19 cases,Ⅱ 5 cases,Gangliogliomas (WHO Ⅰ) were confirmed to all the Specimen by pathological examination,no radiotherapy were done postoperation,the periodic imaging follow-up without recurrence.Conclusions Surgical treatment is the best choise for epilepsy secondary to the temporal lobe gangliogliomas.We could resect the tumor and the epileptogenic zone totally with the help of intracranioelectrodes. Key words: Gangliogliomas;  Epilepsy;  Temporal lobe