2012•Zhonghua xingwei yixue yu naokexue zazhiRequires access
Comparative study on efficacy and quality of life of amisulpride and clozapine in schizophrenia with predominantly negative symptoms
Yongchao Lin, Wen-qian Ou, Ling-en Li
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Abstract
Objective
To investigate the influence on efficacy and quality of life of amisulpride in schizophrenia with predominantly negative symptoms.
Methods
Seventy cases of schizophrenia with predominantly negative symptoms were randomly assigned to amisulpride group and clozapine group for 12weeks.The clinical efficacy and side effects were evaluated with SANS, BPRS and TESS before and 1, 2, 4, 8, 12 weeks after treatment respectively. GQOLI-74 were used to evaluate the patients' quality of life before and after drug administration.
Results
For the last assessment, the score of BPRS decrease to 30.68±4.62 in amisulpride group, was significantly lower than the beginning(P 0.05). And the scores of four domains in GQOLI-74 had been improved significantly in two groups(P<0.01). The domains of physical function, psychological function, and social function in amisulpride was superior to clozapine(P<0.01). The side effects were more in clozapine group than those in amisulpride group.
Conclusion
Amisulpride is as effective as clozapine for the treatment of schizophrenia with predominantly negative symptoms, but it has more advantage than clozapine to improve emotional dull, attention dysfunction and quality of life in schizophrenia with predominantly negative symptoms.
Key words:
Amisulpride; Clozapine; Schizophrenia; Negative symptoms; Efficacy; Quality of life; Comparative study